JARID2

Description		jumonji and AT-rich interaction domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Histone Methyltransferase Complex ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Factor Binding Histone Demethylase Activity Histone Demethylase Activity (H3-trimethyl-K4 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Chromatin Remodeling Central Nervous System Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Histone Methylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Spleen Development Thymus Development Stem Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Leukemia Inhibitory Factor
Pathways		PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronotype ( 30696823) Hand grip strength ( 29691431) Lymphoma ( 23349640) Multiple myeloma ( 27363682) Multiple sclerosis (severity) ( 19010793) Ovarian reserve ( 22116950)
Interacting Genes		3 interacting genes: GATA4 NKX2-5 SETDB1
Entrez ID		3720
HPRD ID		03355
Ensembl ID		ENSG00000008083
Uniprot IDs		Q92833
PDB IDs		5HYN 5LS6 6C23 6C24
Enriched GO Terms of Interacting Partners?
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