JAK3 and STAT5A

Number of citations of the paper that reports this interaction (PubMedID 9047382)
23

Data Source:
HPRD (two hybrid, in vitro)

		JAK3	STAT5A
Description		Janus kinase 3	signal transducer and activator of transcription 5A
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Cytoskeleton Plasma Membrane	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	MAPK Cascade Adaptive Immune Response Negative Regulation Of Dendritic Cell Cytokine Production Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway B Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of FasL Biosynthetic Process Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Defense Response JAK-STAT Cascade Lactation Cytokine-mediated Signaling Pathway Taurine Metabolic Process Interleukin-15-mediated Signaling Pathway Reelin-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Response To Peptide Hormone Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Transcription By RNA Polymerase II JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling	Prolactin receptor signaling Nuclear signaling by ERBB4 Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Tofacitinib Baricitinib
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 27569725 28067908 23128233) Ulcerative colitis ( 28067908)
Interacting Genes		43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC RAB8A SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B TIAF1 UHRF2 VIL1	70 interacting genes: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK MAGEA12 MAPK1 MAPK3 MRPS6 NCOR2 NMI NR3C1 OLIG1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		3718	6776
HPRD ID		02547	03301
Ensembl ID		ENSG00000105639	ENSG00000126561
Uniprot IDs		A0A024R7M7 P52333	A0A384N5W4 A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs		1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4
Enriched GO Terms of Interacting Partners?
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