JAK2 and GRB10

  • Number of citations of the paper that reports this interaction (PubMedID 9632636)
  • 12
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vitro, in vivo)

JAK2

GRB10

Description Janus kinase 2 growth factor receptor bound protein 10
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 23512250)
  • Area under the curve of insulin levels ( 24699409)
  • Birth weight ( 31043758)
  • Blood pressure (smoking interaction) ( 25189868)
  • Body mass index ( 26426971)
  • Body mass index (age <50) ( 26426971)
  • Body mass index x sex x age interaction (4df test) ( 26426971)
  • Chronotype ( 30696823)
  • Corpus callosum mid-anterior volume ( 31530798)
  • Corrected insulin response ( 24699409)
  • Corrected insulin response adjusted for insulin sensitivity index ( 24699409)
  • Diastolic blood pressure ( 30224653)
  • Eosinophil counts ( 27863252)
  • Estimated glomerular filtration rate ( 31152163 31015462)
  • Fasting blood glucose ( 22581228)
  • Fasting blood glucose (BMI interaction) ( 22581228)
  • Femoral neck bone mineral density ( 22504420)
  • Fractures ( 30158200)
  • Heel bone mineral density ( 30598549)
  • Incremental insulin ( 24699409)
  • Insulin levels adjusted for BMI ( 24699409)
  • Metabolite levels ( 23823483)
  • Morning person ( 30696823)
  • Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409)
  • Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901)
  • Schizophrenia (treatment resistant) ( 25223841)
  • Sum eosinophil basophil counts ( 27863252)
  • Systemic sclerosis ( 21779181)
  • Total body bone mineral density ( 29304378)
Interacting Genes 97 interacting genes: ABL1 AGTR1 ARL11 ASS1 BCR BRCA1 CBL CCR5 CRLF2 CSF2RB CSF3R CTLA4 CXCR4 DNAJA3 EGFR ELP2 EPOR ERBB2 ERBB3 EZH2 FES FYN GHR GRB10 GRB2 GTF2I H3-4 HES1 HES5 HSFY1 HSPA8 HTR2A IFNGR1 IFNGR2 IGF1R IKBKG IL12RB2 IL23R IL3RA IL4R IL5RA INSR IRS1 IRS2 JAK3 KIT LEPR LYN MAP3K5 MDK MPL MST1R NFKBIA OSMR PDGFRB PIK3R1 PKD1 PLCG2 PPIA PPP1CC PPP2CA PPP2R1B PPP2R5A PRLR PRMT5 PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN6 PTPRC RAF1 RBMX SH2B1 SH2B2 SHC1 SIRPA SOCS1 SOCS3 STAM STAM2 STAP2 STAT1 STAT2 STAT3 STAT5A STAT5B TEC TNFRSF1A TRAF6 TSHR TUB UBASH3B VAV1 VCP YES1 32 interacting genes: ABL1 AKT1 APP BAIAP2 BCR CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET SRC ZDHHC17
Entrez ID 3717 2887
HPRD ID 00993 03312
Ensembl ID ENSG00000096968 ENSG00000106070
Uniprot IDs A8K910 B4DYV1 O60674 Q13322
PDB IDs 2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4C61 4C62 4D0W 4D0X 4D1S 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA 4P7E 4YTC 4YTF 4YTH 4YTI 4Z32 4ZIM 5AEP 5CF4 5CF5 5CF6 5CF8 5HEZ 5I4N 5L3A 5TQ3 5TQ4 5TQ5 5TQ6 5TQ7 5TQ8 5USY 5USZ 5UT0 5UT1 5UT2 5UT3 5UT4 5UT5 5UT6 5WEV 5WIJ 5WIK 5WIL 5WIM 5WIN 6AAJ 6BBV 6BRW 6BS0 6BSS 6D2I 6DRW 6E2P 6E2Q 6G3C 6M9H 1NRV 3HK0
Enriched GO Terms of Interacting Partners?
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