ITGA7 and CHRNA1

Number of citations of the paper that reports this interaction (PubMedID 10910772)
29

Data Source:
HPRD (in vivo)

		ITGA7	CHRNA1
Description		integrin subunit alpha 7	cholinergic receptor nicotinic alpha 1 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface	Cell Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Cell Junction Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation	Skeletal Muscle Contraction Cation Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential Neuron Cellular Homeostasis
Pathways		Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Galantamine Agmatine
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Atrial fibrillation ( 29892015)
Interacting Genes		4 interacting genes: CHRNA1 FHL2 FHL3 MYOC	4 interacting genes: CHRND CHRNE CHRNG ITGA7
Entrez ID		3679	1134
HPRD ID		02761	00007
Ensembl ID		ENSG00000135424	ENSG00000138435
Uniprot IDs		J3KNV4 Q13683 Q4LE35	P02708 Q53SH4
PDB IDs			1Y5P 1Y5T 1Y6C 4ZJS 5HBT
Enriched GO Terms of Interacting Partners?
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