CHRNA1 and ITGA7

Number of citations of the paper that reports this interaction (PubMedID 10910772)
29

Data Source:
HPRD (in vivo)

		CHRNA1	ITGA7
Description		cholinergic receptor nicotinic alpha 1 subunit	integrin subunit alpha 7
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Cell Junction Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integrin Complex Cell Surface
	Molecular Function	Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Metal Ion Binding
	Biological Process	Skeletal Muscle Contraction Cation Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential Neuron Cellular Homeostasis	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans
Drugs		Galantamine Agmatine
Diseases		Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Atrial fibrillation ( 29892015)	Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		4 interacting genes: CHRND CHRNE CHRNG ITGA7	4 interacting genes: CHRNA1 FHL2 FHL3 MYOC
Entrez ID		1134	3679
HPRD ID		00007	02761
Ensembl ID		ENSG00000138435	ENSG00000135424
Uniprot IDs		P02708 Q53SH4	J3KNV4 Q13683 Q4LE35
PDB IDs		1Y5P 1Y5T 1Y6C 4ZJS 5HBT
Enriched GO Terms of Interacting Partners?
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