IRF3 and SGTA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IRF3	SGTA
Description		interferon regulatory factor 3	small glutamine rich tetratricopeptide repeat containing alpha
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Membrane TRC Complex Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Coregulator Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Transcription By RNA Polymerase II Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Type I Interferon Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Secretion Regulation Of Inflammatory Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Viral Process Ubiquitin-dependent ERAD Pathway Chaperone-mediated Protein Folding Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		28 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26	98 interacting genes: ADIPOQ ADRM1 AGR3 BAG6 BCL2L12 BTC C1QA C1QTNF1 C1QTNF6 C3orf52 CD79B CD99 CD99L2 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KASH5 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NAXD NME3 NR3C1 NXF1 PBXIP1 PCDHA4 PFN2 PGR PIAS1 PLAAT4 PPIB PPIC PPP1R3C PRAP1 PTN RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B
Entrez ID		3661	6449
HPRD ID		04769	04568
Ensembl ID		ENSG00000126456	ENSG00000104969
Uniprot IDs		E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653	O43765
PDB IDs		1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA	2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?
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