CXCL8 and CCL4

Number of citations of the paper that reports this interaction (PubMedID 8077676)
21

Data Source:
HPRD (in vitro)

		CXCL8	CCL4
Description		C-X-C motif chemokine ligand 8	C-C motif chemokine ligand 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Immune Response Cell Cycle Arrest Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Leukocyte Chemotaxis Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell	Monocyte Chemotaxis Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Response To Toxic Substance Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Transcription Lymphocyte Chemotaxis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		ABT-510 MDX-018 Rivanicline Tapinarof
Diseases
GWAS			Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		18 interacting genes: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1	8 interacting genes: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2
Entrez ID		3576	6351
HPRD ID		00909	01657
Ensembl ID		ENSG00000169429	ENSG00000275302
Uniprot IDs		A0A024RDA5 P10145	P13236
PDB IDs		1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6N2U	1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?
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