IL7 and IL2RG

Number of citations of the paper that reports this interaction (PubMedID 11858939)
18

Data Source:
HPRD (in vitro, in vivo)

		IL7	IL2RG
Description		interleukin 7	interleukin 2 receptor subunit gamma
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-7 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Positive Regulation Of Cytokine-mediated Signaling Pathway T Cell Lineage Commitment Humoral Immune Response Cell-cell Signaling Positive Regulation Of Cell Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Interleukin-7-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Bone Resorption Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Organ Growth Homeostasis Of Number Of Cells Within A Tissue Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	MAPK Cascade Immune Response Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Interleukin-7 signaling Interleukin-7 signaling	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Resatorvid
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Blood protein levels ( 30072576) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of white cells ( 27863252) Suicide in bipolar disorder ( 25917933)
Interacting Genes		5 interacting genes: APP CEBPE FBXO7 IL2RG IL7R	25 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3574	3561
HPRD ID		00892	02391
Ensembl ID		ENSG00000104432	ENSG00000147168
Uniprot IDs		A0A0A0MTG5 A8K673 P13232 Q5FBX5	P31785
PDB IDs		1IL7 3DI2 3DI3	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL
Enriched GO Terms of Interacting Partners?
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