IL2RG and IL7R

Number of citations of the paper that reports this interaction (PubMedID 8266077)
169

Data Source:
HPRD (in vivo)

		IL2RG	IL7R
Description		interleukin 2 receptor subunit gamma	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	MAPK Cascade Immune Response Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Positive Regulation Of Phagocytosis	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Membrane Organization Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of STAT Cascade
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Denileukin diftitox Aldesleukin Resatorvid
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (adrenergics, inhalants) ( 31015401) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633)
Interacting Genes		25 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	104 interacting genes: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		3561	3575
HPRD ID		02391	00893
Ensembl ID		ENSG00000147168	ENSG00000168685
Uniprot IDs		P31785	P16871
PDB IDs		1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL	3DI2 3DI3 3UP1 5J11 6P50 6P67
Enriched GO Terms of Interacting Partners?
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