FOXP1 and LRRK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		FOXP1	LRRK1
Description		forkhead box P1	leucine rich repeat kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Mitochondrion Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding Protein Binding Identical Protein Binding Protein Self-association Metal Ion Binding Androgen Receptor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Osteoclast Differentiation Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor Production Somatic Stem Cell Population Maintenance Chemokine (C-C Motif) Ligand 2 Secretion Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway T Follicular Helper Cell Differentiation Interleukin-21 Secretion Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Interleukin-12 Secretion	Protein Phosphorylation Osteoclast Development Bone Resorption Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Anorexia nervosa ( 31308545) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254 31527586) Basal cell carcinoma ( 31174203 27539887) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Familial lung adenocarcinoma ( 29924316) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Height ( 28552196) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998 24002674 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lung function (FVC) ( 30804560) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 24076602) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 27863252) Non-melanoma skin cancer ( 29739929) Nose size ( 27182965) Number of sexual partners ( 30643258) Optic disc size ( 31809533) Primary sclerosing cholangitis ( 27992413) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Red blood cell count ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Selective IgA deficiency ( 27723758) Squamous cell carcinoma ( 26829030) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 27841878) Tooth agenesis (maxillary lateral incisors) ( 29364747) Vitiligo ( 27723757)	Central corneal thickness ( 28171582 31798171 29760442) Corneal structure ( 23291589) Height ( 28552196)
Interacting Genes		9 interacting genes: AURKA CTBP1 FOXP2 FOXP4 IKZF1 IL3RA LRRK1 MNAT1 NCOR2	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CHGB CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SELENOS SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TEX33 TIRAP TM2D3 VGLL4
Entrez ID		27086	79705
HPRD ID		18518	14319
Ensembl ID		ENSG00000114861	ENSG00000154237
Uniprot IDs		A0A3B3IS20 A0A3B3IT66 Q548T7 Q8N2P0 Q8TEA2 Q9H334	Q38SD2
PDB IDs		2KIU
Enriched GO Terms of Interacting Partners?
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