IL3 and IL3RA

Number of citations of the paper that reports this interaction (PubMedID 8649415)
12

Data Source:
HPRD (in vitro, in vivo)

		IL3	IL3RA
Description		interleukin 3	interleukin 3 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Cytokine Receptor Activity Interleukin-3 Receptor Activity Cytokine Binding
	Biological Process	MAPK Cascade Regulation Of Cytokine-mediated Signaling Pathway Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Peptidyl-tyrosine Phosphorylation	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Amlexanox Zinc	Sargramostim
Diseases
GWAS		Body mass index ( 28552196) Crohn's disease ( 28067908 22412388 21102463) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 30423114 24390342) Ulcerative colitis ( 28067908)	Schizophrenia ( 17522711)
Interacting Genes		5 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD	15 interacting genes: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2
Entrez ID		3562	3563
HPRD ID		00987	02392
Ensembl ID		ENSG00000164399	ENSG00000185291
Uniprot IDs		P08700	P26951
PDB IDs		1JLI 5UV8 5UWC	4JZJ 5UV8 5UWC
Enriched GO Terms of Interacting Partners?
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