FASLG and TEC

Number of citations of the paper that reports this interaction (PubMedID 19807924)
3

Data Source:
BioGRID (unspecified method)

		FASLG	TEC
Description		Fas ligand	tec protein tyrosine kinase
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Interferon-gamma Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Endothelial Cell Apoptotic Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 25920553 24999842) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Vitiligo ( 27723757)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)
Interacting Genes		74 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	31 interacting genes: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG FBXO7 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		356	7006
HPRD ID		00610	02786
Ensembl ID		ENSG00000117560	ENSG00000135605
Uniprot IDs		P48023 Q53ZZ1	P42680
PDB IDs		1BZI 4MSV 5L19 5L36	2LUL
Enriched GO Terms of Interacting Partners?
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