SKA2 and HMOX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SKA2	HMOX2
Description		spindle and kinetochore associated complex subunit 2	heme oxygenase 2
Image
GO Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule	Cell Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Protein Binding Microtubule Binding	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Heme degradation Neutrophil degranulation Iron uptake and transport
Drugs			NADH Stannsoporfin
Diseases
GWAS		Cognitive function ( 25644384) Testicular germ cell tumor ( 23666239)	Erectile dysfunction ( 30583798)
Interacting Genes		4 interacting genes: HMOX2 PRKD3 SKA1 SPC24	35 interacting genes: A2M APP ATP5F1B BLOC1S2 CEBPZ CEP126 COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 LMNA LRIF1 MARK3 MED31 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		348235	3163
HPRD ID		13306	00783
Ensembl ID		ENSG00000182628	ENSG00000103415
Uniprot IDs		J3KSP0 Q8WVK7	A0A087WT44 B3KSE0 P30519
PDB IDs		4AJ5	2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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