APOE and MAPT

Number of citations of the paper that reports this interaction (PubMedID 8620924)
14

Data Source:
BioGRID (pull down, unspecified method)
HPRD (in vitro, in vivo)

		APOE	MAPT
Description		apolipoprotein E	microtubule associated protein tau
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Chylomicron Neuronal Cell Body Synaptic Cleft Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Glutamatergic Synapse Extracellular Vesicle Lipoprotein Particle	Extracellular Region Cell Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Structural Molecule Activity Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Antioxidant Activity Identical Protein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Chelating Activity Protein Dimerization Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Intermembrane Cholesterol Transfer Activity	DNA Binding AT DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein Binding, Bridging Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Response To Reactive Oxygen Species Retinoid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Regulation Of Transcription By RNA Polymerase II Triglyceride Metabolic Process Cholesterol Catabolic Process Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Synaptic Transmission, Cholinergic Long-term Memory Cholesterol Metabolic Process Gene Expression Negative Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Cholesterol Esterification Positive Regulation Of Cholesterol Efflux Lipid Transport Involved In Lipid Storage Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Long-chain Fatty Acid Transport Protein Import Virion Assembly CGMP-mediated Signaling Negative Regulation Of Blood Coagulation Regulation Of Axon Extension Neuron Projection Development Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly High-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Locomotory Exploration Behavior Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Vasodilation Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Complex Assembly Negative Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Post-translational Protein Modification Reverse Cholesterol Transport Cellular Protein Metabolic Process Positive Regulation By Host Of Viral Process Regulation Of Innate Immune Response Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Lipid Biosynthetic Process Intracellular Transport Regulation Of Neuronal Synaptic Plasticity Artery Morphogenesis Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Protein Metabolic Process Maintenance Of Location In Cell Fatty Acid Homeostasis Positive Regulation Of Dendritic Spine Development Regulation Of Proteasomal Protein Catabolic Process Response To Caloric Restriction Triglyceride Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cholesterol Metabolic Process Negative Regulation Of Triglyceride Metabolic Process AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Cellular Oxidant Detoxification Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Dendritic Spine Maintenance Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Heparan Sulfate Binding Positive Regulation Of Heparan Sulfate Proteoglycan Binding Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Regulation Of Amyloid Fibril Formation Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Regulation Of Behavioral Fear Response	Microtubule Cytoskeleton Organization Microglial Cell Activation Internal Protein Amino Acid Acetylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Signaling Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Negative Regulation Of Kinase Activity Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Diacylglycerol Kinase Activity Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Response To DNA Damage Stimulus
Pathways		Nuclear signaling by ERBB4 Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport	Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Human Serum Albumin Zinc Copper	Lansoprazole Astemizole Paclitaxel Docetaxel
Diseases		Lipoprotein glomerulopathy Hyperlipoproteinemia, type III; Dysbetalipoproteinemia Alzheimer's disease (AD)	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Age-related macular degeneration ( 23326517 23455636) Alzheimer disease and age of onset ( 26830138) Alzheimer's disease ( 17975299 22832961 24770881 20460622 30636644 17998437 18823527 19734902 19734903 21627779 24755620 19125160 20061627 22245343 31473137) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 17474819 20885792 23565137 26339675 30617256 28714976) Alzheimer's disease (onset at age over 80) ( 30979435) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 23562540 21123754 23419831) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Alzheimer's disease progression score ( 29860282) Alzheimerâ€™s disease (clinical subgroup AD+) ( 31473137) Alzheimerâ€™s disease (clinical subgroup AD++) ( 31473137) Alzheimerâ€™s disease (clinical subgroup AD+++) ( 31473137) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD+) ( 31473137) Apolipoprotein Levels ( 23031429) Blood metabolite ratios ( 24816252) Blood protein levels ( 30072576 29875488) Body fat percentage ( 26833246) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 19567438 18439548 18439552 23844046) C-reactive protein levels ( 29403010 30388399) Cardiovascular risk factors ( 20838585) Carotid intima media thickness ( 30510157) Carotid intima media thickness (maximum) ( 31801372) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 25027320) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 30319691 28641921 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30319691 28641921) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 24097068 28270201 19060911 25961943 20686565) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870) Cognitive decline (age-related) ( 28078323 24468470) Cognitive impairment test score ( 30319691) Coronary artery disease ( 29212778 30104761 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Dementia with Lewy bodies ( 29263008 31065058) Family history of Alzheimer's disease ( 30617256) Free cholesterol levels in large LDL ( 29084231) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 24097068 21909109 28270201 19060911 30275531 25961943 20686565) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 29403010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hippocampal atrophy ( 22745009) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Ideal cardiovascular health (clinical) ( 27179730) Immature fraction of reticulocytes ( 27863252) Late-onset Alzheimer's disease ( 29360470) LDL cholesterol ( 23726366 24097068 18802019 24507774 18193043 18193044 20864672 26160806 19060906 19060911 25961943 23067351 20686565) LDL cholesterol levels ( 28334899 26763881 28371326 17463246) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lewy body disease ( 25188341) Lipid metabolism phenotypes ( 22286219) Lipid or lipoprotein levels ( 23696881) Lipid traits ( 30576415 24023260) Lipoprotein (a) levels ( 28512139) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Lobar intracerebral hemorrhage ( 31430377) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511 31484785) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Low density lipoprotein cholesterol levels ( 30718733 29403010 28548082) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Moderate to vigorous physical activity levels ( 29899525) Mortality ( 27029810) Neuritic plaque ( 31497858) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 31497858) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Parental lifespan ( 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 31484785 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease (age of onset) ( 30957308) Platelet count ( 27863252) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Psychosis and Alzheimer's disease ( 22005930) Pulse pressure ( 30224653 30578418) Quantitative traits ( 19197348) Red cell distribution width ( 27863252 28957414) Response to statins (LDL cholesterol change) ( 25350695 22331829) Resting heart rate ( 27798624) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total cholesterol levels ( 29084231) Sphingolipid levels ( 26068415) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30718733 28334899 29403010 28548082) Total cholesterol levels in LDL ( 29084231) Triglyceride levels ( 30718733 28334899 29403010) Triglycerides ( 24507774 19060911 25961943 20686565 26582766) Type 2 diabetes ( 27189021 30297969 28869590) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Vigorous physical activity ( 29899525)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 29892015) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) Head circumference (infant) ( 22504419) Headache ( 29397368) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Parkinson's disease ( 20711177 21292315 19915575 25064009 31660654 24842889 28892059 22438815 20070850 21044948 24511991 21738487) Plasma t-tau levels ( 28100725) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 30089514 21685912 31059154) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Subcortical brain region volumes ( 25607358)
Interacting Genes		55 interacting genes: A2M ALB ANKH APP ARFGAP1 CDC37 CNTF CSNK2A1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 SCARB1 SORL1 ST13 TIMM29 TREM2 TYRO3 VLDLR ZNF558	128 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE APP ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CHEK1 CHEK2 CREBBP CSNK1A1 CSNK1D CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FKBP5 FYN GRB2 GSK3A GSK3B HDAC6 HOOK3 HSP90AA1 HSPA8 HSPB1 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK2 MARK3 MARK4 MASP1 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTK2B PTPA PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SIRT1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 USP9Y YWHAB YWHAZ
Entrez ID		348	4137
HPRD ID		00135	01142
Ensembl ID		ENSG00000130203	ENSG00000186868
Uniprot IDs		A0A0S2Z3D5 P02649	A0A024R9Y0 A0A024R9Y1 A0A024RA17 A0A024RA19 B3KTM0 P10636
PDB IDs		1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B 6NCN 6NCO	1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6N4P 6NWP 6NWQ 6ODG 6QJH 6QJM 6QJP 6QJQ
Enriched GO Terms of Interacting Partners?
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