IFNB1 and IFNAR2

Number of citations of the paper that reports this interaction (PubMedID 10395669)
7

Data Source:
HPRD (in vivo)

		IFNB1	IFNAR2
Description		interferon beta 1	interferon alpha and beta receptor subunit 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Chloramphenicol O-acetyltransferase Activity	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Blood Coagulation Response To Virus Cytokine-mediated Signaling Pathway Natural Killer Cell Activation B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway	Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Response To Interferon-beta Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs		Beta-D-Glucose	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant omega interferon
Diseases
GWAS		Axial length ( 24144296)	Attention deficit hyperactivity disorder ( 30563984) Cerebellum white matter volume ( 31530798) Crohn's disease ( 23128233) Type 2 diabetes ( 30130595)
Interacting Genes		2 interacting genes: IFNAR1 IFNAR2	14 interacting genes: IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB RACK1 STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		3456	3455
HPRD ID		00972	03850
Ensembl ID		ENSG00000171855	ENSG00000159110
Uniprot IDs		P01574	P48551 Q9BUA0
PDB IDs		1AU1	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?
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