IFNB1 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 1834641)
6

Data Source:
HPRD (in vivo)

		IFNB1	IFNAR1
Description		interferon beta 1	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding Chloramphenicol O-acetyltransferase Activity	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Blood Coagulation Response To Virus Cytokine-mediated Signaling Pathway Natural Killer Cell Activation B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway	JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs		Beta-D-Glucose	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant Natural alpha interferon omega interferon
Diseases
GWAS		Axial length ( 24144296)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		2 interacting genes: IFNAR1 IFNAR2	24 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		3456	3454
HPRD ID		00972	00126
Ensembl ID		ENSG00000171855	ENSG00000142166
Uniprot IDs		P01574	A0A494C0E2 P17181
PDB IDs		1AU1	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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