HTR2C and LIN7C

Number of citations of the paper that reports this interaction (PubMedID 12006486)
38

Data Source:
HPRD (in vivo)

		HTR2C	LIN7C
Description		5-hydroxytryptamine receptor 2C	lin-7 homolog C, crumbs cell polarity complex component
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Serotonin receptors G alpha (q) signalling events	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Tramadol Citalopram Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Epicept NP-1 Sertindole Mianserin Asenapine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Setiptiline Sarpogrelate Tiapride
Diseases
GWAS			Bone mineral density (paediatric, skull) ( 24945404) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)
Interacting Genes		8 interacting genes: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1	5 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12
Entrez ID		3358	55327
HPRD ID		02429	17279
Ensembl ID		ENSG00000147246	ENSG00000148943
Uniprot IDs		K9J958 P28335	Q9NUP9
PDB IDs		6BQG 6BQH	3LRA
Enriched GO Terms of Interacting Partners?
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