HTR2C

Description		5-hydroxytryptamine receptor 2C
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GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Tramadol Citalopram Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Epicept NP-1 Sertindole Mianserin Asenapine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Setiptiline Sarpogrelate Tiapride
Diseases
GWAS
Interacting Genes		8 interacting genes: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1
Entrez ID		3358
HPRD ID		02429
Ensembl ID		ENSG00000147246
Uniprot IDs		K9J958 P28335
PDB IDs		6BQG 6BQH
Enriched GO Terms of Interacting Partners?
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