HPX and TP63

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HPX	TP63
Description		hemopexin	tumor protein p63
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Dendrite Protein-containing Complex
	Molecular Function	Protein Binding Heme Transporter Activity Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding WW Domain Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Heme Transport Viral Process Hemoglobin Metabolic Process Heme Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Replicative Cell Aging Skeletal System Development Establishment Of Planar Polarity Epithelial Cell Development Chromatin Remodeling Apoptotic Process Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Cell Proliferation Proximal/distal Pattern Formation Multicellular Organism Aging Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skin Morphogenesis Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Female Genitalia Morphogenesis Protein Tetramerization Neuron Apoptotic Process Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Somatic Stem Cell Population Maintenance Cranial Skeletal System Development Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development
Pathways		Scavenging of heme from plasma	Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases			Limb-mammary syndrome ADULT syndrome Split-hand/foot malformation (SHFM) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome
GWAS		Blood protein levels ( 29875488)	Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 24163127 20972438) Brain imaging ( 20100581) Circulating leptin levels in high cardiovascular risk ( 31766143) Cleft lip with or without cleft palate ( 28054174) EGFR mutation-positive lung adenocarcinoma ( 27501781) Lung adenocarcinoma ( 28604730 22797724 20871597) Lung cancer ( 28604730 21725308 23143601 24880342) Lung cancer in never smokers ( 31009812) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Orofacial clefts ( 28054174) Pancreatic cancer ( 29422604 26098869) Postoperative stroke after cardiac surgery ( 30678657) Psoriasis ( 25903422) Psoriasis vulgaris ( 26626624) Squamous cell carcinoma ( 26829030) Systemic lupus erythematosus ( 28714469) Urinary bladder cancer ( 20348956 18794855)
Interacting Genes		2 interacting genes: GLUD1 TP63	36 interacting genes: BAG6 BTRC CCNC CDC20 CDKN2A COPS6 CSNK2A1 CSNK2A2 CSNK2B DAXX EMX1 EP300 GCGR GRB2 HIPK2 HNRNPAB HP HPX ITCH ITIH4 KAT2B MDM4 NIPSNAP3A ORM1 PINX1 PML PPP1R13B PPP2R5A RACK1 RCHY1 SCAF4 SLC35A3 TP53 TP73 UBE2I WT1
Entrez ID		3263	8626
HPRD ID		00793	04469
Ensembl ID		ENSG00000110169	ENSG00000073282
Uniprot IDs		P02790 Q9BS19	A0A0S2Z4N5 A0A0S2Z4N6 A0A141PNN3 A0A141PNN4 B7Z8X6 C9D7D0 Q9H3D4
PDB IDs			1RG6 2NB1 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z 6FGN
Enriched GO Terms of Interacting Partners?
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