APCS and FCGR2B

Number of citations of the paper that reports this interaction (PubMedID 11359830)
48

Data Source:
HPRD (in vitro)

		APCS	FCGR2B
Description		amyloid P component, serum	Fc fragment of IgG receptor IIb
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Dendritic Spine Cell Body
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Identical Protein Binding Virion Binding Unfolded Protein Binding	Amyloid-beta Binding Protein Binding Low-affinity IgG Receptor Activity IgG Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Complement Activation, Classical Pathway Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Follicular Dendritic Cell Activation Mature B Cell Differentiation Involved In Immune Response Follicular B Cell Differentiation Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of B Cell Antigen Processing And Presentation Negative Regulation Of Immunoglobulin Production Regulation Of Adaptive Immune Response Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Receptor-mediated Endocytosis Phagocytosis, Engulfment Defense Response Inflammatory Response Immune Response Signal Transduction Response To Bacterium Regulation Of Signaling Receptor Activity Viral Process Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cerebellum Development Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-10 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Macrophage Activation Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Innate Immune Response Mast Cell Activation Positive Regulation Of JNK Cascade Negative Regulation Of Cytokine Secretion Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Cellular Response To Molecule Of Bacterial Origin Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Neuron Death Negative Regulation Of Neutrophil Activation Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Dendritic Cell Differentiation
Pathways		Amyloid fiber formation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Zinc Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper	Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Antithymocyte immunoglobulin (rabbit) Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-reactive protein ( 22939635)	Birth weight ( 31043758 27680694) Blood protein levels ( 30072576 29875488 28240269) Granulocyte count ( 27863252) Hemoglobin concentration ( 27863252) IgG levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Lipid metabolism phenotypes ( 22286219) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Offspring birth weight ( 31043758) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Rheumatoid arthritis ( 30423114) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 27863252)
Interacting Genes		17 interacting genes: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	16 interacting genes: AP3B1 APCS BLK CRP ERG28 GAB1 GRB2 INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PRKCA PTPN11 PTPN6
Entrez ID		325	2213
HPRD ID		00101	06849
Ensembl ID		ENSG00000132703	ENSG00000072694
Uniprot IDs		P02743 V9HWP0	P31994
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	2FCB 3WJJ 5OCC
Enriched GO Terms of Interacting Partners?
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