HNRNPC and KPNA4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HNRNPC	KPNA4
Description		heterogeneous nuclear ribonucleoprotein C	karyopherin subunit alpha 4
Image
GO Annotations	Cellular Component	Nuclear Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome	Nuclear Pore Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Splicing RNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase ATP-dependent Chromatin Remodeling 3'-UTR-mediated MRNA Stabilization	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Process Response To Hydrogen Peroxide
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 21738484) Height ( 31562340)	Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		51 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CELF1 CSNK1A1 CSNK2A1 CSNK2A2 DHX9 EPS8 ERG ESR1 FAS FXR2 GRB2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KRAS LMO2 LMO3 PALB2 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I YWHAE YWHAQ ZFYVE26 ZNF581	20 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 GTF2IRD1 HIF1A HNRNPC KPNB1 MAT2B NTRK3 PLAA RAC1 RCC1 RECQL TGM2 TP53 WT1
Entrez ID		3183	3840
HPRD ID		01243	04275
Ensembl ID		ENSG00000092199	ENSG00000186432
Uniprot IDs		P07910	O00629
PDB IDs		1TXP 1WF2 2MXY 2MZ1 3LN4	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB
Enriched GO Terms of Interacting Partners?
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