HMMR and CDH13

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		HMMR	CDH13
Description		hyaluronan mediated motility receptor	cadherin 13
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Caveola Adherens Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Catenin Complex Anchored Component Of Membrane Neuron Projection Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome GABA-ergic Synapse
	Molecular Function	Protein Binding Hyaluronic Acid Binding	Calcium Ion Binding Cytoskeletal Protein Binding Low-density Lipoprotein Particle Binding Cadherin Binding Adiponectin Binding Lipoprotein Particle Binding
	Biological Process	Regulation Of G2/M Transition Of Mitotic Cell Cycle Hyaluronan Catabolic Process	Mitotic Cell Cycle Cell Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Multicellular Organism Development Negative Regulation Of Cell Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Rac Protein Signal Transduction Lamellipodium Assembly Regulation Of Endocytosis Positive Regulation Of Cell Migration Adherens Junction Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelial Cell Migration Keratinocyte Proliferation Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Positive Chemotaxis Localization Within Membrane Low-density Lipoprotein Particle Mediated Signaling Cell-cell Adhesion
Pathways		Hyaluronan uptake and degradation AURKA Activation by TPX2	Adherens junctions interactions
Drugs		Hyaluronic acid
Diseases
GWAS		Metabolite levels ( 23823483)	Adiponectin levels ( 20876611 22479202 22065538 20887962 21771975 24105470) Adolescent idiopathic scoliosis ( 31417091 30395268) Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Alcohol consumption (heavy vs. light/non-drinkers) ( 27911795) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756) Blood pressure ( 17903302) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 30104761 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Crohn's disease ( 28067908) D-dimer levels ( 21502573) Daytime sleep phenotypes ( 27126917) Dental caries (decayed, missing and filled teeth) ( 31533690) Depression (quantitative trait) ( 20800221) Diastolic blood pressure ( 27841878 31170924 30578418) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Erectile dysfunction ( 30583798) Feeling hurt ( 29500382) Feeling tense ( 29500382) Gait speed in old age ( 28077804) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Height ( 20189936) Hippocampal volume ( 31530798) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Hypertension ( 19304780) Hypothyroidism ( 27182965) IgE levels in asthmatics (D.f. specific) ( 23967269) Maximal oxygen uptake response ( 25729143) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Precuneus cortex volume ( 31530798) Pulse pressure ( 28135244 27841878 28739976 30578418) Rapid automised naming of digits ( 30741946) Refractive astigmatism ( 30306274) Response to amphetamines ( 22952603) Response to antipsychotic treatment ( 20195266) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (adiponectin levels) ( 23149075) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Schizophrenia ( 23358160) Seasonality and depression ( 30217971) Short-term memory (digit-span task) ( 30741946)
Interacting Genes		15 interacting genes: ACTB BACH1 CALM1 CD44 CDH13 GREB1 IL24 ITIH5 MAPK3 MORN4 NAT2 SVIL THRSP TPX2 TUBB2A	10 interacting genes: ADIPOQ AURKA CASP8 CCND1 CHEK2 HMMR MAPK6 MTNR1B PTPN1 RAD51
Entrez ID		3161	1012
HPRD ID		02963	03219
Ensembl ID		ENSG00000072571	ENSG00000140945
Uniprot IDs		O75330	B7Z3H7 B7Z9B1 P55290
PDB IDs			2V37
Enriched GO Terms of Interacting Partners?
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