HLA-G and TAP2

Number of citations of the paper that reports this interaction (PubMedID 9103419)
4

Data Source:
HPRD (in vivo)

		HLA-G	TAP2
Description		major histocompatibility complex, class I, G	transporter 2, ATP binding cassette subfamily B member
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Early Endosome Plasma Membrane External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Filopodium Membrane Early Endosome Membrane Cis-Golgi Network Membrane MHC Class I Protein Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Speck Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Peptide Antigen Binding CD8 Receptor Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding ATP Binding Peptide Antigen-transporting ATPase Activity Peptide-transporting ATPase Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances TAP1 Binding Tapasin Binding Peptide Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Peripheral B Cell Tolerance Induction Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response Cellular Defense Response Negative Regulation Of Angiogenesis Positive Regulation Of Interleukin-12 Production Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of Protein Kinase B Signaling Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Negative Regulation Of G0 To G1 Transition Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of Dendritic Cell Differentiation	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Peptide Antigen Transport Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Childhood ear infection ( 27182965) Colorectal cancer ( 30529582) Crohn's disease ( 22412388) IgE levels ( 22075330) IgM levels ( 28628107) Lung adenocarcinoma ( 28604730) Non-albumin protein levels ( 29403010) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)	Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Composite immunoglobulin trait (IgA/IgG) ( 28628107) IgA nephropathy ( 25305756) Lymphoma ( 23349640) Nephropathy ( 21399633) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787)
Interacting Genes		9 interacting genes: B2M CD8A COPB1 KIR2DL4 KLRD1 LILRB1 LILRB2 TAP1 TAP2	9 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP
Entrez ID		3135	6891
HPRD ID		00834	01360
Ensembl ID		ENSG00000204632	ENSG00000204267
Uniprot IDs		P17693 Q31611 Q6DU14	Q03519 Q5JNW1 Q9UP03 X5CMH5
PDB IDs		1YDP 2D31 2DYP 3BZE 3CDG 3CII 3KYN 3KYO 6AEE 6K60	5U1D
Enriched GO Terms of Interacting Partners?
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