TAP2 and PSMG3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TAP2	PSMG3
Description		transporter 2, ATP binding cassette subfamily B member	proteasome assembly chaperone 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Speck Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Protein Binding ATP Binding Peptide Antigen-transporting ATPase Activity Peptide-transporting ATPase Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances TAP1 Binding Tapasin Binding Peptide Transmembrane Transporter Activity
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To ER Transport Peptide Antigen Transport Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases		Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Asthma ( 31619474) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Composite immunoglobulin trait (IgA/IgG) ( 28628107) IgA nephropathy ( 25305756) Lymphoma ( 23349640) Nephropathy ( 21399633) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Urate levels in lean individuals ( 25811787)	Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		9 interacting genes: APP HLA-C HLA-G PSMB5 PSMB8 PSMG3 RBM18 TAP1 TAPBP	6 interacting genes: PSMB1 PSMB3 PSMB4 PSMB5 PSMG4 TAP2
Entrez ID		6891	84262
HPRD ID		01360	14404
Ensembl ID		ENSG00000204267	ENSG00000157778
Uniprot IDs		Q03519 Q5JNW1 Q9UP03 X5CMH5	A0A024R806 Q9BT73
PDB IDs		5U1D	2Z5E 6JPT
Enriched GO Terms of Interacting Partners?
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