HINT1 and CDC16

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HINT1	CDC16
Description		histidine triad nucleotide binding protein 1	cell division cycle 16
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Cytosol Spindle Microtubule
	Molecular Function	Nucleotide Binding Protein Kinase C Binding Hydrolase Activity	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Signal Transduction Purine Ribonucleotide Catabolic Process Positive Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Adenosine monophosphate Guanosine-5'-Monophosphate 5'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5'-Ditungstate 8-Bromo-Adenosine-5'-Monophosphate
Diseases
GWAS		Blood protein levels ( 29875488) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Metabolite levels ( 23823483) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		4 interacting genes: CDC16 MITF SP1 TRIM29	23 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC27 DAB2 DNAJA1 FBXO5 FTH1 HINT1 LINC00839 MAD2L1 MTNR1B PPP5C SKIL SMAD2 SMAD3 TUBGCP3 UBE2S XRCC5
Entrez ID		3094	8881
HPRD ID		03204	04587
Ensembl ID		ENSG00000169567	ENSG00000130177
Uniprot IDs		A0A384NPU2 P49773	A0A024RDZ2 A0A3B3ISD2 B2RCW0 Q13042
PDB IDs		1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH 4ZKL 4ZKV 5ED3 5ED6 5EMT 5I2E 5I2F 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM4 5KM6 5KMA 5KMB 5KMC 5O8I 5WA8 5WA9 5WAA 6B42 6G9Z 6J53 6J58 6J5S 6J5Z 6J64 6J65 6N3V 6N3W 6N3X 6N3Y	3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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