UBE2K and RNF144A

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (two hybrid)

		UBE2K	RNF144A
Description		ubiquitin conjugating enzyme E2 K	ring finger protein 144A
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GO Annotations	Cellular Component	Cell Nucleus Cytosol Filopodium Tip	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)	Allergic rhinitis ( 30013184) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)
Interacting Genes		79 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF144A RNF167 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SENP1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM63 UBA1 UBB UBC UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	16 interacting genes: E2F1 E2F2 E2F3 E2F4 EGFR PARP1 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32
Entrez ID		3093	9781
HPRD ID		04165	11510
Ensembl ID		ENSG00000078140	ENSG00000151692
Uniprot IDs		B3KSH4 B4DIZ2 P61086	P50876
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7	1WIM
Enriched GO Terms of Interacting Partners?
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