ANXA6 and MLH1

Number of citations of the paper that reports this interaction (PubMedID 20706999)
7

Data Source:
BioGRID (two hybrid)

		ANXA6	MLH1
Description		annexin A6	mutL homolog 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosomal Membrane Focal Adhesion Membrane Late Endosome Membrane Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome	Synaptonemal Complex Male Germ Cell Nucleus Cell Nucleus Nucleoplasm Chiasma Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Phosphatidylserine Binding Calcium Channel Activity Calcium Ion Binding Protein Binding GTP Binding Calcium-dependent Phospholipid Binding Lipid Binding Ligand-gated Ion Channel Activity Cholesterol Binding Chondroitin Sulfate Binding Identical Protein Binding Calcium-dependent Protein Binding Actin Filament Binding	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Neural Crest Cell Migration Plasma Membrane Repair Growth Plate Cartilage Chondrocyte Differentiation Regulation Of Muscle Contraction Ion Transmembrane Transport Negative Regulation Of Sequestering Of Calcium Ion Mitochondrial Calcium Ion Homeostasis Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly
Pathways		Smooth Muscle Contraction	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination
Drugs
Diseases			Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Endometrial Cancer Ovarian cancer
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 25574825) Psoriatic arthritis ( 26626624)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)
Interacting Genes		14 interacting genes: A2M CDC73 CR2 ERBB2 LMNA MLH1 MTNR1B RASA1 RHOU S100A1 S100B SMURF1 SNCA TPD52	84 interacting genes: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CBY2 CCDC33 CDCA7L CEP126 CEP76 CKAP4 CKB DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GPX1 GSTP1 IGKC KPNA2 LGALS4 LY96 MAGEA8 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RADX RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SQSTM1 STAP2 TASOR2 TLE5 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZBED1 ZC3H11A ZER1
Entrez ID		309	4292
HPRD ID		00231	00390
Ensembl ID		ENSG00000197043	ENSG00000076242
Uniprot IDs		A0A0S2Z2Z6 P08133	A0A024R2S9 P40692 Q59EG3
PDB IDs		1M9I	3RBN 4P7A 5U5P
Enriched GO Terms of Interacting Partners?
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