MLH1 and FBXO32

Number of citations of the paper that reports this interaction (PubMedID 20706999)
7

Data Source:
BioGRID (two hybrid)

		MLH1	FBXO32
Description		mutL homolog 1	F-box protein 32
Image			No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Cell Nucleus Nucleoplasm Chiasma Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex	Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Synapsis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly	Protein Polyubiquitination Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Post-translational Protein Modification Cellular Response To Dexamethasone Stimulus
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination	Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Endometrial Cancer Ovarian cancer
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)	Atrial fibrillation ( 30061737 29892015) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998 29785010 31959993 30054594) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		84 interacting genes: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ANXA6 AP2B1 APRT ARAF ASS1 ATF2 BLM BRCA1 CAB39L CAPN5 CASP3 CBY2 CCDC33 CDCA7L CEP126 CEP76 CKAP4 CKB DDX47 EEF1G EEF2 EIF2A ELP6 EXO1 EXOC3 FBXO32 FCGBP FLNB FRMD6 GABARAP GPX1 GSTP1 IGKC KPNA2 LGALS4 LY96 MAGEA8 MAP2K6 MBD4 MLH3 MSH3 MSH4 MUC2 MYC MYL6 MYOG NDRG1 NT5C3B ORC4 PARP12 PARVA PCNA PMS1 PMS2 PSMA1 PTGDS PTPRH RAD23B RAD9A RADX RAPGEFL1 SEC61A1 SELENBP1 SERPINF1 SQSTM1 STAP2 TASOR2 TLE5 TRIM23 TRIM29 TXN TXN2 UBOX5 VAMP8 ZBED1 ZC3H11A ZER1	8 interacting genes: CDC34 EIF3F MLH1 MYOD1 SH3GL1 SH3GL2 SH3GL3 SKP1
Entrez ID		4292	114907
HPRD ID		00390	05966
Ensembl ID		ENSG00000076242	ENSG00000156804
Uniprot IDs		A0A024R2S9 P40692 Q59EG3	A0A024R9F3 I6L984 Q0VAQ6 Q498Y9 Q969P5
PDB IDs		3RBN 4P7A 5U5P
Enriched GO Terms of Interacting Partners?
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