ZNRD1 and SACS

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNRD1	SACS
Description		zinc ribbon domain containing 1	sacsin molecular chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase I Complex	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber
	Molecular Function	Nucleic Acid Binding DNA-directed 5'-3' RNA Polymerase Activity Zinc Ion Binding	Hsp70 Protein Binding Chaperone Binding Proteasome Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription MRNA Cleavage Positive Regulation Of Gene Expression, Epigenetic	Protein Folding Negative Regulation Of Inclusion Body Assembly
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		AIDS progression ( 19115949) Anger ( 24489884) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) HIV-1 control ( 20041166) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730)	Blood pressure (smoking interaction) ( 25189868) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)
Interacting Genes		17 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 UBE2I ZNF593	5 interacting genes: ACTN4 PICK1 TSC22D4 UBE3A ZNRD1
Entrez ID		30834	26278
HPRD ID		09601	05135
Ensembl ID		ENSG00000066379	ENSG00000151835
Uniprot IDs		Q2L6J2 Q9P1U0	Q9NZJ4
PDB IDs			1IUR 3O10 5V44 5V45 5V46 5VSX 5VSZ
Enriched GO Terms of Interacting Partners?
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