ANXA5 and EIF4G1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		ANXA5	EIF4G1
Description		annexin A5	eukaryotic translation initiation factor 4 gamma 1
Image
GO Annotations	Cellular Component	Extracellular Region Intracellular Cytoplasm Cytosol Focal Adhesion External Side Of Plasma Membrane Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Endothelial Microparticle	Nucleus Cytoplasm Cytosol Polysome Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Platelet Degranulation Signal Transduction Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Calcium Ion Transmembrane Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Viral Process Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of MRNA Stability Positive Regulation Of Neuron Differentiation Regulation Of Gene Silencing By MiRNA Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Death Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly Positive Regulation Of MRNA Cap Binding Positive Regulation Of MiRNA Mediated Inhibition Of Translation Regulation Of Polysome Binding
Pathways		Platelet degranulation	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		L-Alpha-Glycerophosphorylserine L-thioproline K201 L-Alpha-Glycerophosphorylethanolamine 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Copper
Diseases
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Resting-state electroencephalogram vigilance ( 29703947)	Menarche (age at onset) ( 25231870)
Interacting Genes		17 interacting genes: ACTG1 APP COL10A1 COL2A1 EED EIF4G1 FDFT1 IFNGR2 ITGB5 KDR LAMC3 PPP2R1B SUPT4H1 TERF1 TERF2 TERF2IP TINF2	26 interacting genes: ANXA5 AP2M1 CENPU EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 SRPK2 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		308	1981
HPRD ID		00568	06774
Ensembl ID		ENSG00000164111	ENSG00000114867
Uniprot IDs		P08758 V9HWE0	B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65
PDB IDs		1ANW 1ANX 1AVH 1AVR 1HAK 1HVD 1HVE 1HVF 1HVG 1SAV 2XO2 2XO3	1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46
Enriched GO Terms of Interacting Partners?
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