EIF4G1 and AP2M1

		EIF4G1	AP2M1
Description		eukaryotic translation initiation factor 4 gamma 1	adaptor related protein complex 2 subunit mu 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Membrane Eukaryotic Translation Initiation Factor 4F Complex	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Extracellular Exosome
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Identical Protein Binding Molecular Adaptor Activity	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Ion Channel Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Viral Process Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of MRNA Stability Positive Regulation Of Neuron Differentiation Regulation Of Gene Silencing By MiRNA Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neuron Death Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly Positive Regulation Of MRNA Cap Binding Positive Regulation Of MiRNA Mediated Inhibition Of Translation Regulation Of Polysome Binding	Intracellular Protein Transport Vesicle Budding From Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Cellular Protein-containing Complex Assembly Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis Regulation Of Vesicle Size Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Major depressive disorder ( 22472876)
Interacting Genes		26 interacting genes: ANXA5 AP2M1 CENPU EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 SRPK2 TRAF2 UBE3A UPF2 ZFYVE9	51 interacting genes: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CKS1B CORO7 CRIP1 CSNK2B CTLA4 DAB2 DCX DNAJB11 DPPA2 DVL2 EHD2 EIF4G1 ETV5 FGF12 FURIN FXR2 GAK GRIN2B IKZF1 IL1RAP JADE1 KCNJ11 LAMP1 LPP LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TASOR TBC1D5 TGOLN2 UBC XPA ZBTB8A
Entrez ID		1981	1173
HPRD ID		06774	03014
Ensembl ID		ENSG00000114867	ENSG00000161203
Uniprot IDs		B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65	B4DNB9 E9PFW3 Q96CW1
PDB IDs		1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46	1H6E 6BNT
Enriched GO Terms of Interacting Partners?
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