CFHR1 and PRDX4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CFHR1	PRDX4
Description		complement factor H related 1	peroxiredoxin 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Protein-containing Complex Blood Microparticle	Extracellular Region Cell Nucleus Cytoplasm Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Thioredoxin Peroxidase Activity
	Biological Process	Complement Activation Regulation Of Complement Activation Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Regulation of Complement cascade	Neutrophil degranulation
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Complement C3 and C4 levels ( 23028341) IgA nephropathy ( 25305756) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)
Interacting Genes		4 interacting genes: APOA1 CFH LBP PRDX4	25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		3078	10549
HPRD ID		00602	05935
Ensembl ID		ENSG00000244414	ENSG00000123131
Uniprot IDs		Q03591	Q13162 V9HW63
PDB IDs		3ZD2 4MUC	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP
Enriched GO Terms of Interacting Partners?
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