PRDX4 and PRDX1

Number of citations of the paper that reports this interaction (PubMedID 9388242)
82

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PRDX4	PRDX1
Description		peroxiredoxin 4	peroxiredoxin 1
Image
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Cytoplasm Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Space Cell Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Identical Protein Binding Cadherin Binding
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Cellular Response To Stress Erythrocyte Homeostasis Cellular Response To Oxidative Stress Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Oxidation-reduction Process Regulation Of NIK/NF-kappaB Signaling
Pathways		Neutrophil degranulation	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			Zinc Copper Artenimol
Diseases
GWAS			Blood protein levels ( 28240269) Body mass index ( 26426971)
Interacting Genes		25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	26 interacting genes: ABL1 ADH5 BTRC CALM1 CLEC4G EGFR EXOSC3 GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ
Entrez ID		10549	5052
HPRD ID		05935	01458
Ensembl ID		ENSG00000123131	ENSG00000117450
Uniprot IDs		Q13162 V9HW63	A0A384NPQ2 Q06830
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP	2RII 3HY2 4XCS
Enriched GO Terms of Interacting Partners?
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