HEXB and EIF2D

Number of citations of the paper that reports this interaction (PubMedID 7299841)
2

Data Source:
HPRD (in vitro)

		HEXB	EIF2D
Description		hexosaminidase subunit beta	eukaryotic translation initiation factor 2D
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Cell Membrane Azurophil Granule Lumen Azurophil Granule Lysosomal Lumen Extracellular Exosome	Cytoplasm Cytosol Nuclear Body Cytosolic Small Ribosomal Subunit
	Molecular Function	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Identical Protein Binding N-acetyl-beta-D-galactosaminidase Activity	Translation Initiation Factor Activity Signaling Receptor Activity
	Biological Process	Skeletal System Development Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Cellular Calcium Ion Homeostasis Lysosome Organization Penetration Of Zona Pellucida Sensory Perception Of Sound Locomotory Behavior Male Courtship Behavior Regulation Of Cell Shape Phospholipid Biosynthetic Process Oligosaccharide Catabolic Process Lipid Storage Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process Myelination Neutrophil Degranulation Astrocyte Cell Migration Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Neuromuscular Process Controlling Balance	Formation Of Translation Preinitiation Complex Intracellular Protein Transport Ribosome Disassembly IRES-dependent Viral Translational Initiation
Pathways		Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXB causes GM2G2 Neutrophil degranulation
Drugs		Pyrimethamine 2-Acetamido-2-Deoxy-D-Glucono-1,5-Lactone 3ar,5r,6s,7r,7ar-5-Hydroxymethyl-2-Methyl-5,6,7,7a-Tetrahydro-3ah-Pyrano[3,2-D]Thiazole-6,7-Diol (2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: CSNK2B EIF2D	2 interacting genes: ACHE HEXB
Entrez ID		3074	1939
HPRD ID		06043	01057
Ensembl ID		ENSG00000049860	ENSG00000143486
Uniprot IDs		A0A024RAJ6 P07686 Q5URX0	P41214
PDB IDs		1NOU 1NOW 1NP0 1O7A 1QBD 2GJX 2GK1 3LMY 5BRO	5OA3 5OA9 5W2F
Enriched GO Terms of Interacting Partners?
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