HEXB

Description		hexosaminidase subunit beta
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GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Cell Membrane Azurophil Granule Lumen Azurophil Granule Lysosomal Lumen Extracellular Exosome
	Molecular Function	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Identical Protein Binding N-acetyl-beta-D-galactosaminidase Activity
	Biological Process	Skeletal System Development Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Cellular Calcium Ion Homeostasis Lysosome Organization Penetration Of Zona Pellucida Sensory Perception Of Sound Locomotory Behavior Male Courtship Behavior Regulation Of Cell Shape Phospholipid Biosynthetic Process Oligosaccharide Catabolic Process Lipid Storage Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process Myelination Neutrophil Degranulation Astrocyte Cell Migration Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Neuromuscular Process Controlling Balance
Pathways		Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXB causes GM2G2 Neutrophil degranulation
Drugs		Pyrimethamine 2-Acetamido-2-Deoxy-D-Glucono-1,5-Lactone 3ar,5r,6s,7r,7ar-5-Hydroxymethyl-2-Methyl-5,6,7,7a-Tetrahydro-3ah-Pyrano[3,2-D]Thiazole-6,7-Diol (2r,3r,4s,5r)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: CSNK2B EIF2D
Entrez ID		3074
HPRD ID		06043
Ensembl ID		ENSG00000049860
Uniprot IDs		A0A024RAJ6 P07686 Q5URX0
PDB IDs		1NOU 1NOW 1NP0 1O7A 1QBD 2GJX 2GK1 3LMY 5BRO
Enriched GO Terms of Interacting Partners?
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