HEXA and GM2A

Number of citations of the paper that reports this interaction (PubMedID 9217013)
1

Data Source:
HPRD (in vitro)

		HEXA	GM2A
Description		hexosaminidase subunit alpha	GM2 ganglioside activator
Image
GO Annotations	Cellular Component	Membrane Azurophil Granule Lysosomal Lumen Extracellular Exosome	Extracellular Region Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein Heterodimerization Activity N-acetyl-beta-D-galactosaminidase Activity	Lipid Transporter Activity Phospholipase Activator Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosphingolipid Metabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Neutrophil Degranulation Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity
Pathways		Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXA causes GM2G1	Glycosphingolipid metabolism Neutrophil degranulation
Drugs			Platelet Activating Factor Isopropyl Alcohol Lauric Acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant	GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS			Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		2 interacting genes: GM2A USP22	3 interacting genes: GPLD1 HEXA PLD2
Entrez ID		3073	2760
HPRD ID		06040	02034
Ensembl ID		ENSG00000213614	ENSG00000196743
Uniprot IDs		A0A0S2Z3W3 B4DVA7 H3BP20 P06865	P17900
PDB IDs		1QBC 2GJX 2GK1	1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?