GM2A and HEXA

Number of citations of the paper that reports this interaction (PubMedID 9217013)
1

Data Source:
HPRD (in vitro)

		GM2A	HEXA
Description		GM2 ganglioside activator	hexosaminidase subunit alpha
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GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Membrane Azurophil Granule Lysosomal Lumen Extracellular Exosome
	Molecular Function	Lipid Transporter Activity Phospholipase Activator Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity	Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Protein Heterodimerization Activity N-acetyl-beta-D-galactosaminidase Activity
	Biological Process	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Neutrophil Degranulation Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosphingolipid Metabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Catabolic Process Keratan Sulfate Catabolic Process
Pathways		Glycosphingolipid metabolism Neutrophil degranulation	Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXA causes GM2G1
Drugs		Platelet Activating Factor Isopropyl Alcohol Lauric Acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant	GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		3 interacting genes: GPLD1 HEXA PLD2	2 interacting genes: GM2A USP22
Entrez ID		2760	3073
HPRD ID		02034	06040
Ensembl ID		ENSG00000196743	ENSG00000213614
Uniprot IDs		P17900	A0A0S2Z3W3 B4DVA7 H3BP20 P06865
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9	1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?
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