HDAC2 and MTA2

Number of citations of the paper that reports this interaction (PubMedID 22939629)
262

Data Source:
BioGRID (biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology)

		HDAC2	MTA2
Description		histone deacetylase 2	metastasis associated 1 family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Sin3 Complex NuRD Complex Protein-containing Complex ESC/E(Z) Complex Sin3-type Complex	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Sequence-specific DNA Binding NF-kappaB Binding Promoter-specific Chromatin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Remodeling Maintenance Of Chromatin Silencing Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Response To Caffeine Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Response To Nicotine Response To Cocaine Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Positive Regulation Of Oligodendrocyte Differentiation Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Male Mating Behavior Cellular Response To Dopamine Negative Regulation Of Peptidyl-lysine Acetylation	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator
Pathways		p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Factors involved in megakaryocyte development and platelet production	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs		Lovastatin Theophylline Valproic Acid Aminophylline Oxtriphylline Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Tixocortol Mocetinostat
Diseases
GWAS		Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		106 interacting genes: ANTXR1 APPL1 ARID4A AURKA BCL11A BRCA1 BRMS1 BRMS1L BUB3 CABIN1 CDC20 CDH1 CDKN1A CDYL CHD3 CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 FOXO3 FTCD FYN GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LAMA4 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA REV3L RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 STK25 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TNS4 TOP2A TOP2B TP53 TREML2 USP4 VHL YY1 ZBTB16 ZNF461	22 interacting genes: APPL1 APPL2 BCL11B ESR1 FKBP3 H3-4 HDAC2 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C YY1
Entrez ID		3066	9219
HPRD ID		05521	07233
Ensembl ID		ENSG00000196591	ENSG00000149480
Uniprot IDs		Q92769	A0A024R534 O94776
PDB IDs		3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O
Enriched GO Terms of Interacting Partners?
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