HBG2 and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 4403130)
22

Data Source:
HPRD (in vitro)

		HBG2	CYB5R3
Description		hemoglobin subunit gamma 2	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Cytosol Hemoglobin Complex Haptoglobin-hemoglobin Complex Blood Microparticle	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen
	Molecular Function	Peroxidase Activity Oxygen Carrier Activity Oxygen Binding Heme Binding Haptoglobin Binding Hemoglobin Alpha Binding Organic Acid Binding Metal Ion Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding NAD Binding FAD Binding
	Biological Process	Blood Coagulation Oxygen Transport Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation Oxidation-reduction Process
Pathways		Factors involved in megakaryocyte development and platelet production	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Beta thalassemia/hemoglobin E disease ( 20183929) Hemoglobin ( 28548082) Hemoglobin levels ( 26366553) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Malate levels ( 31560688) Mean corpuscular hemoglobin concentration ( 28453575) Red cell distribution width ( 27863252)	Initial pursuit acceleration ( 29064472)
Interacting Genes		5 interacting genes: APP CYB5R3 HBB RPSA SMAD5	11 interacting genes: ARSA CYB5A CYCS GAS1 HBG2 L3MBTL2 RPS6KB1 SBF1 SPP1 TUBGCP6 XPNPEP3
Entrez ID		3048	1727
HPRD ID		00792	08942
Ensembl ID		ENSG00000196565	ENSG00000100243
Uniprot IDs		D9YZU9 P69892	P00387
PDB IDs		1FDH 4MQJ 4MQK	1M91 1UMK
Enriched GO Terms of Interacting Partners?
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