HADHB and HSD17B10

Number of citations of the paper that reports this interaction (PubMedID 22496890)
5

Data Source:
BioGRID (two hybrid)

		HADHB	HSD17B10
Description		hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	hydroxysteroid 17-beta dehydrogenase 10
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Mitochondrial Nucleoid	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex
	Molecular Function	RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Acetyl-CoA C-myristoyltransferase Activity	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Dihydrotestosterone 17-beta-dehydrogenase Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Fatty Acid Beta-oxidation Cardiolipin Acyl-chain Remodeling	Lipid Metabolic Process Mitochondrion Organization Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Oxidation-reduction Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing
Pathways		Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA	tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion
Drugs			NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases			2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS			Bipolar disorder ( 31043756) Body mass index ( 28892062)
Interacting Genes		14 interacting genes: ANXA7 APP CDKN1A CHCHD4 COX17 GRB7 HSD17B10 HSPB2 RCC1 SMN1 SUOX TIMM8B TK1 TNNI3K	31 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PINK1 PRKN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1
Entrez ID		3032	3028
HPRD ID		00887	02223
Ensembl ID		ENSG00000138029	ENSG00000072506
Uniprot IDs		F5GZQ3 P55084	A0A0S2Z410 Q99714
PDB IDs		5ZQZ 5ZRV 6DV2	1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?
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