H1-4 and CBX3

Number of citations of the paper that reports this interaction (PubMedID 16127177)
84

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		H1-4	CBX3
Description		H1.4 linker histone, cluster member	chromobox 3
Image
GO Annotations	Cellular Component	Nuclear Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Nuclear Heterochromatin	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin Senescence-associated Heterochromatin Focus Site Of DNA Damage
	Molecular Function	Double-stranded DNA Binding RNA Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding AMP Binding Chromatin DNA Binding Nucleosomal DNA Binding DATP Binding ADP Binding	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs		Copper
Diseases
GWAS			Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CBX1 CBX3 CBX5 IL7R IRAK4 PRKCA	32 interacting genes: ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 DNMT3B DSN1 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 KLF11 L3MBTL1 LBR MGA MIS12 MKI67 NSD3 NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF496
Entrez ID		3008	11335
HPRD ID		07513	05130
Ensembl ID		ENSG00000168298	ENSG00000122565
Uniprot IDs		A3R0T8 P10412	A4D177 Q13185
PDB IDs		3TZD 5JJZ 6H8P	2L11 3DM1 3KUP 3TZD 5T1I
Enriched GO Terms of Interacting Partners?
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