ANAPC2 and ANAPC11

Number of citations of the paper that reports this interaction (PubMedID 11739784)
59

Data Source:
HPRD (in vivo)

		ANAPC2	ANAPC11
Description		anaphase promoting complex subunit 2	anaphase promoting complex subunit 11
Image
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation Regulation Of Mitotic Cell Cycle Phase Transition	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: ANAPC11 ANAPC7 CDC20 CDC26 CDC27 FBXO5 FZR1 MAD2L1 PTTG1 SMAD2 SUMO2 UBE2C UBE2D2 UBE2S UFD1	26 interacting genes: ANAPC10 ANAPC2 ANAPC4 CAPN11 CCNB1 CDC16 CDC20 CUL5 FBXO5 FZR1 MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U ZAP70
Entrez ID		29882	51529
HPRD ID		07367	12452
Ensembl ID		ENSG00000176248	ENSG00000141552
Uniprot IDs		Q9UJX6	A0A024R8S1 A0A087X1B5 Q9NYG5
PDB IDs		4UI9 4YII 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6OB1 6Q6G 6Q6H	2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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