ANAPC11 and NKD2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ANAPC11	NKD2
Description		anaphase promoting complex subunit 11	NKD inhibitor of WNT signaling pathway 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex	Cytoplasm Plasma Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Exocytic Vesicle Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	Calcium Ion Binding Protein Binding Growth Factor Binding Ubiquitin Protein Ligase Binding Myosin Heavy Chain Binding ATPase Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Exocytosis Positive Regulation Of Protein Processing Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Pancreatic cancer ( 25086665) QT interval ( 24952745) Red cell distribution width ( 27863252 28957414)
Interacting Genes		26 interacting genes: ANAPC10 ANAPC2 ANAPC4 CAPN11 CCNB1 CDC16 CDC20 CUL5 FBXO5 FZR1 MAK MLKL NKD2 PTTG1 RNF111 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U ZAP70	9 interacting genes: ANAPC11 CDKN1A FBXO7 FUS GRB2 LNX1 RCHY1 TGFA VDR
Entrez ID		51529	85409
HPRD ID		12452	08483
Ensembl ID		ENSG00000141552	ENSG00000145506
Uniprot IDs		A0A024R8S1 A0A087X1B5 Q9NYG5	Q969F2
PDB IDs		2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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