ICOS and NUFIP2

Number of citations of the paper that reports this interaction (PubMedID 29352114)
9

Data Source:
BioGRID (unspecified method)

		ICOS	NUFIP2
Description		inducible T cell costimulator	nuclear FMR1 interacting protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Body Polysomal Ribosome
	Molecular Function	Protein Binding	RNA Binding Protein Binding
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion
Pathways
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Depression ( 29700475) Headache ( 29397368) Heel bone mineral density ( 30598549)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	25 interacting genes: CRK EFEMP2 FMR1 ICOS KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LGALS13 PCSK5 RGS17 STAT3 TNFRSF4 TRAF1 YWHAG
Entrez ID		29851	57532
HPRD ID		09196	11764
Ensembl ID		ENSG00000163600	ENSG00000108256
Uniprot IDs		Q53QY6 Q9Y6W8	Q7Z417
PDB IDs
Enriched GO Terms of Interacting Partners?
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