ICOS and WIF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ICOS	WIF1
Description		inducible T cell costimulator	WNT inhibitory factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Cell Surface
	Molecular Function	Protein Binding	Signaling Receptor Binding Protein Binding Wnt-protein Binding
	Biological Process	T Cell Tolerance Induction Immune Response T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Cell-cell Adhesion	Signal Transduction Multicellular Organism Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Fat Cell Differentiation Anatomical Structure Development
Pathways			TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Alopecia areata ( 20596022 25608926) Aluminium levels ( 26025379) Body mass index ( 28892062) Celiac disease ( 20190752) Diastolic blood pressure ( 30224653) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Ulcerative colitis ( 26192919)	Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 22504421) Macular thickness ( 30535121) Post bronchodilator FEV1/FVC ratio ( 26634245) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)
Interacting Genes		4 interacting genes: ICOSLG NUFIP2 RC3H1 WIF1	8 interacting genes: AURKA CRADD FGFR4 ICOS KRTAP10-3 KRTAP10-8 RB1CC1 RPL37
Entrez ID		29851	11197
HPRD ID		09196	05541
Ensembl ID		ENSG00000163600	ENSG00000156076
Uniprot IDs		Q53QY6 Q9Y6W8	Q9Y5W5
PDB IDs			2D3J 2YGN 2YGO 2YGP 2YGQ
Enriched GO Terms of Interacting Partners?
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