GTF2E2 and XPA

Number of citations of the paper that reports this interaction (PubMedID 7876263)
46

Data Source:
HPRD (in vitro)

		GTF2E2	XPA
Description		general transcription factor IIE subunit 2	XPA, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Nuclear Speck	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Intercellular Bridge
	Molecular Function	DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Toxic Substance UV Protection Regulation Of Autophagy Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Global Genome Nucleotide-excision Repair UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Cognitive performance ( 20125193) Metabolite levels (X-11787) ( 23934736)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		23 interacting genes: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KLF5 MCC MDM2 MNAT1 NUP62 SND1 SUPT16H TBP XPA	25 interacting genes: AP2M1 ATM ATR DDB1 DDB2 ERCC1 ERCC4 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PCNA PRKDC RASSF1 RHOU RPA1 RPA2 RPA4 TRIM27 XAB2 XPC
Entrez ID		2961	7507
HPRD ID		01800	02045
Ensembl ID		ENSG00000197265	ENSG00000136936
Uniprot IDs		P29084	P23025
PDB IDs		1D8J 1D8K 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L	1D4U 1XPA 2JNW 6J44 6RO4
Enriched GO Terms of Interacting Partners?
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