GSN and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 11733011)
3

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GSN	ACTN4
Description		gelsolin	actinin alpha 4
Image
GO Annotations	Cellular Component	Ruffle Podosome Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Protein-containing Complex Secretory Granule Lumen Myelin Sheath Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Stress Fiber Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Cytosol Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Nuclear Body Z Disc Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Myosin II Binding Actin Filament Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Phagocytosis, Engulfment Aging Positive Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Atrophy Extracellular Matrix Disassembly Actin Filament Polymerization Regulation Of Cell Adhesion Protein Destabilization Tissue Regeneration Sequestering Of Actin Monomers Neutrophil Degranulation Cellular Protein Metabolic Process Actin Nucleation Response To Ethanol Negative Regulation Of Viral Entry Into Host Cell Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Response To Folic Acid Actin Filament Capping Cilium Assembly Cellular Response To Cadmium Ion Cellular Response To Interferon-gamma Regulation Of Podosome Assembly Actin Filament Reorganization Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Bicellular Tight Junction Assembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Protein Localization To Bicellular Tight Junction Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Amyloid fiber formation	Platelet degranulation Nephrin family interactions
Drugs		Zinc Latrunculin A Copper
Diseases		Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Blood protein levels ( 30072576)	Heart rate ( 23583979) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		24 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN RAB14 STK39 TNIK TOM1L1 VASP VCL VDAC1	50 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		2934	81
HPRD ID		00674	05222
Ensembl ID		ENSG00000148180	ENSG00000130402
Uniprot IDs		A0A0A0MS51 A0A0A0MT01 A0A384MEF1 B7Z4U6 P06396	A0A0S2Z3G9 O43707
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5DD2 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6Q9R 6Q9Z 6QBF 6QW3	1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?