GRM4 and GNA15

Number of citations of the paper that reports this interaction (PubMedID 8863838)
15

Data Source:
HPRD (in vivo)

		GRM4	GNA15
Description		glutamate metabotropic receptor 4	G protein subunit alpha 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Presynapse	Cell Heterotrimeric G-protein Complex Plasma Membrane Synapse
	Molecular Function	Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Glutamic Acid
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) BMI at birth ( 31575865) Body mass index ( 26426971 28892062) Inflammatory skin disease ( 25574825) Osteosarcoma ( 23727862) Pulse pressure ( 30578418) Regular attendance at a gym or sports club ( 29970889) Tonsillectomy ( 27182965 28928442) Uterine fibroids ( 31649266)	Glucose homeostasis traits ( 25524916) Heart failure ( 20445134)
Interacting Genes		4 interacting genes: CALM1 FLNA GNA15 GNAQ	19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		2914	2769
HPRD ID		04978	00760
Ensembl ID		ENSG00000124493	ENSG00000060558
Uniprot IDs		A1L4F9 A8K0J8 B7ZLU9 Q14833	P30679
PDB IDs
Enriched GO Terms of Interacting Partners?
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