TBK1 and AGAP2

		TBK1	AGAP2
Description		TANK binding kinase 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body
	Molecular Function	Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding	GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Negative Regulation Of Gene Expression Viral Process Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Peptidyl-serine Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Neuron Death Positive Regulation Of Xenophagy	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Activation Of Protein Kinase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity
Pathways		IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Netrin-1 signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 29566793 27455348) Lung adenocarcinoma ( 28604730)	Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)
Interacting Genes		52 interacting genes: AGAP2 AGO2 APP ATG9A AVIL AZI2 CALCOCO2 CDC37 CDC42BPG CYLD HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 MAP1LC3B MARCHF9 MAVS MBP MIB1 MIB2 MPP3 MTPAP NCK1 NEDD4 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SCN7A SIKE1 SMCR8 SMURF1 SOCS2 SQSTM1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TRIM27 TXLNG XIAP YAF2	14 interacting genes: AKT1 ARF1 CDC42 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 RAC1 RAC2 RHOA TBK1
Entrez ID		29110	116986
HPRD ID		05322	05687
Ensembl ID		ENSG00000183735	ENSG00000135439
Uniprot IDs		Q9UHD2	A0A024RB55 F8VVT9 Q99490
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B	2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?
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