AGAP2 and HOMER2

Number of citations of the paper that reports this interaction (PubMedID 14528310)
114

Data Source:
HPRD (in vitro, in vivo)

		AGAP2	HOMER2
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	homer scaffold protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Dendrite Stereocilium Tip Neuron Projection Neuronal Cell Body Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding	Actin Binding Protein Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G Protein-coupled Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Activation Of Protein Kinase Activity Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of 1-phosphatidylinositol-3-kinase Activity	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		Netrin-1 signaling	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)	Tourette syndrome ( 30818990)
Interacting Genes		14 interacting genes: AKT1 ARF1 CDC42 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 RAC1 RAC2 RHOA TBK1	12 interacting genes: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1
Entrez ID		116986	9455
HPRD ID		05687	07269
Ensembl ID		ENSG00000135439	ENSG00000103942
Uniprot IDs		A0A024RB55 F8VVT9 Q99490	Q9NSB8
PDB IDs		2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?
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